Prevention of recurrent Urinary Tract Infections in patients with spinal cord injury

Prevention of recurrent Urinary Tract Infections in patients with spinal cord injury

Need:  Urinary tract infection (UTI) is one of the most debilitating complications of paralysis causing pain and discomfort, where an individual cannot control their bladder due to the damage caused by spinal cord injury and often requires antibiotic treatment.

Antibiotics are regularly used to treat UTI’s however, antibiotic resistance is now a world-wide health concern and it is widely agreed that further research is needed to identify alternative methods of treatment.

In light of this, SMSR has initiated a clinical randomized control trial – known as the PRsSUTINeB  study  – to investigate if an oral immunotherapy treatment, taken every day in the form of a capsule for 3 months, can help to prevent UTI’s in people with reduced or no bladder control due to spinal cord injury, multiple sclerosis, transverse myelitis or cauda equine syndrome. This vaccine has the potential to prevent UTIs in as many as 83% of people living with spinal cord injury.

It will also look to improve our understanding of the signs and/ or symptoms associated with UTIs ( that require antibiotic treatment) that participants may experience throughout the study.  For more information about the study please contact the Research Project Manager at

Project Stage: Recruitment

Location: Stoke Mandeville Spinal Research, Stoke Mandeville Hospital

Project Manager:  James Cooper SMSR –

Research Team:
Mr Fadel Derry (Consultant, NSIC)
Mr Nigel Henderson (Orthopedic Surgeon, NSIC)
Dr Jasmine Hearn (Psychologist, University of Buckingham)

Emily Whicher (Pysiotherapist, NSIC & Clinical Research Therapist, SMSR)
Oxford Team
Reading Team

Funding: NIHR Funded – £281,960

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